Monday, May 9, 2011

organic chemistry GET AT ME

042

So like, here’s what I learned this week:

For a primary substrate (1°R-X), you can’t get SN1 or E1 because those go through a carbocation intermediate (C+) which, like, totally isn’t stable because it would much rather be secondary or tertiary. So you can’t have SN1 or E1, but you can have SN2 or E2, and which one you get is dependant on how much beta-branching there is, with more branching favoring E2 because the nucleophile (nuc:) in SN2 comes in from the back (and reverses the stereochemistry), which it can’t do if there’s too much branching in the way.

For 2° R-X, you can get, like, a crap ton of things… There’s SN1 and E1 if it’s a poor nuc: with a polar protic solvent (so it like has O-H and N-H bonds), with more E1 if it’s at higher temperature. And then if it’s a good nuc: with a polar aprotic solvent, you’ll probably get either SN2 or… or some other sh*t.

Screw orgo. I’M DONE.

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dress – thrifted // shoes – Bensimon // jacket – Madewell // bag – Longchamp (spelled correctly! sheesh) // belt - thrifted

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